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Description
Therefore, structurally modified analogues with an altered OXM pharmacological profile have been produced with longer duration of action, good safety profile, and positive effects on body weight (and glucose metabolism) management in animal studies (143)

The mechanism is scientifically sound and consistently supported by animal data, but human efficacy and safety have not been established through clinical trials

concentrations greater than 60 M were not tested due to known cytotoxic effects in 3T3-L1 cells (see Figure 1)

However, it significantly elevates cortisol and prolactin, creating metabolic complications

Metabolic Rewiring: By stopping the conversion of nicotinamide (NAM) into 1-methylnicotinamide (1-MNA), the cell is forced to recycle NAM into NAD+

[PubMed: 12805393] 76
