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Yes, it's generally recommended to refrigerate HCG after mixing to maintain its potency and stability

Inhibition of renal prostaglandin synthesis can lead to a variety of detrimental effects if kidney function is less than optimal, including fluid and electrolyte disorders, acute renal dysfunction, nephrotic syndrome, interstitial nephritis, and renal papillary necrosis

It plays a role wherever purity is critical

doi: 10.1042/bj3260167

The mechanism of sepsis induced edema is posited to be due to increased vascular permeability via degradation of the endothelial glycocalyx

2006, Philadelphia: Lippincott, Williams and Wilkins, 537-544