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As already mentioned, depending on the size of the cobalamin pool, there are more or less losses, and these should be covered if approximately the same reserve values are to be maintained, taking into account the percentage of absorption: Note: For vegans/ovo-lacto vegetarians: The weekly protocol is usually considered more convenient and is cheaper than the daily protocol

Topical opioids on large wounds carry a potential risk of systemic absorption and central nervous system side effects, particularly in vulnerable populations such as elderly patients, young subjects, or those with renal impairment [153]