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B12 is one of those key nutrients

doi: 10.1016/j.freeradbiomed.2007.02.001

Mapping studies of the GS substrate binding sites indicate that the regions of the active site that bind glycine and the cysteinyl moiety of -glutamylcysteine are highly specific, while the L--glutamyl moiety can be replaced by a variety of analogs (Oppenheimer et al., 1979)

(5) For instance, if you metabolize caffeine more slowly, you will be impacted more intensely by caffeine than someone who metabolizes caffeine faster

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Finally, partial inhibition of GSH may induce stress responses in cancer cells, leading to the upregulation of detoxifying enzymes and drug resistance