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When comparing with some well-known inhibitors of system xc, erastin was the most efficient inhibitor acting at low micromolar concentrations

Many studies had small sample sizes or no long-term follow-up

This article elaborates on the following three main aspects: the molecular mechanisms underlying pyroptosis and the development of promising therapeutics that target pyroptosis, the relationship between pyroptosis, inflammation, and tumors, and the application of nano-targeting materials in tumor treatments

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