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This process, known as bioavailability, can be inefficient and unpredictable

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IGF/IGFBPs level alterations in MetS have been, to some extent, observed, however the exact mechanism has not been elucidatedstill it suggests a trend towards IGF-1 local or systemic deficiency or availability

Full-length BDNF protein cannot be taken as a supplement because it does not cross the blood-brain barrier and breaks down rapidly in the digestive system