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High disease activity is associated with an increased risk of infection in patients with rheumatoid arthritis

These include Nrf2/GPX4, Nrf2/HO-1, FTH1, SLC7A11, Nrf2/HO-1, and the system Xc-GSH-GPX4

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For example, opioids decrease pulmonary perfusion via hypoxia-induced pulmonary vasoconstriction 143 , and by direct pulmonary vasoconstriction 144,145 by mechanisms including centrally-mediated activation of sympathetic nerve activity to the lungs 146 , and induction of histamine release in the lungs 144,147