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Progress in Materials Science

This research paper describes how scientists designed and created the drug cagrilintide

Rights and permissions About this article Cite this article Obermann, M., Krasniqi, M., Ewers, N

Stapled peptides consisting of either L- or D-amino acids have been discovered with both classes of molecules binding to Mdm2 and MdmX to displace the p53 N-terminal helix 6,11,12,13,14

27 May 2011

Approximately 50 mg of frozen cecal content was added to 0.1 mm glass bead-containing tubes (PowerBead Tubes, Qiagen) prefilled with 300 l RLT buffer (RNeasy mini kit, Qiagen) supplemented with -mercaptoethanol (10 l/ml, Sigma-Aldrich) and 1 ml TRIzol (Invitrogen)