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A limitation to the therapeutic potential of the senolytic pan-BCL inhibitors ABT-263/ABT-737 is their tendency to cause severe thrombocytopenia(Schoenwaelder et al., 2011)

[DOI] [PubMed] [Google Scholar] 62.Green AR, Mitchell BD, Tordoff AF, Youdim MBH

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Clinical Evidence Current clinical evidence for both peptides remains notably limited in comparison to the extensive body of preclinical data

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