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FIGURE 8 PCs and their metabolites exhibit significant therapeutic potential in the pathogenesis of diabetic nephropathy through multiple mechanisms, including antioxidant and anti-fibrotic effects, as well as the regulation of key signaling pathways

G., Cagna M., Richelmi P., Ferrigno A., Berardo C

The mice were sacrificed on 21st day after the intratracheal administration of BLM or saline

Several studies have identified multiple genetic risk factors for PD such as SNCA (encoding -synuclein), parkin RBR E3 ubiquitin protein ligase ( PRKN) , PTEN-induced kinase 1 (PINK1) , DJ-1 and Leucine-rich repeat kinase 2 ( LRRK2 ) [140]

peripheral vascular thrombosis Hematological : Polycythemia vera (a rare type of blood cancer) Gastrointestinal : Mild, transient diarrhea Dermatological : Itching

To circumvent this problem, we developed an endosome-escaping peptide comprised of histidine-rich sequences (Fig