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When mitochondrial function is severely compromised, the integrity of the mitochondrial membrane is disrupted, leading to the release of pro-apoptotic factors into the cytoplasm

K m values for both homocysteine and cysteine were essentially identical for the four constructs at ~0.3 and ~20 mM, respectively

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J Clin Oncol 35(29):JCO2017738401, 2017