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607 Clausenamide, an alkaloid isolated from Clausena lansium , interacts directly with Ser663 of ALOX5, blocking the nuclear translocation of ALOX5, alleviating lipid peroxide accumulation and ferroptosis in dopaminergic neurons, significantly improving behavioral deficits in PD mouse models, and providing an attractive strategy for PD treatment

But the drug is expensive, costing about $400 per injection

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This is supported by the observation that most effective antidepressants, including SSRIs and SNRIs, increase BDNF expression over time

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Why Muscle Spasms Occur Potential Causes Muscle spasms can strike suddenly, developing into an uncomfortable inconvenience of uncontrollable muscle contractions