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However, in these studies the number of patients was small, and further investigation is warranted
Furthermore, upregulation of the PI3K/AKT/mTOR pathway is involved in the neuroinflammation and neuronal autophagy of ASD [29, 60]

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The process of generating ATP naturally produces reactive oxygen species (ROS), which are highly volatile molecules that can cause severe cellular damage if left unchecked
Accordingly, we next employed preclinical models of kidney injury to gain mechanistic insights into the potential interplay between TMAO and kidney function and the putative molecular nature of the 2nd hit
