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Given that PI3K is an important hub in the function of insulin/IGF-1-dependent regulation, this kinase has been inhibited by PTEN phosphatase (see above) and SH2-containing inositol 5-phosphatase 2 (SHIP2) which is enriched in mouse brain and its overexpression impaired memory formation [53] (Fig

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Second, GSNO may help maintain or restore endothelium derived NO signaling, preserving vasorelaxation, minimizing reperfusion-associated vasoconstriction, and supporting coronary perfusion