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This study provides brain-wide evidence that regional mitochondrial diversity and network organization explain a large part of the variance on behavioural manifestations of anxiety in mice, supporting the idea that mitochondrial phenotypes vary across circuits and individuals
[DOI] [PMC free article] [PubMed] [Google Scholar] 71.Zhang C., Liu J., Liang Y., Wu R., Zhao Y., Hong X., Lin M., Yu H., Liu L., Levine A.J., et al
BioMed Res Int 2017:4862861
Initial treatment for patients with neurological involvement follows British National Formulary (BNF) guidance: Hydroxocobalamin 1 mg intramuscularly on alternate days for approximately 2-3 weeks (or until no further improvement) Maintenance therapy then consists of hydroxocobalamin 1 mg intramuscularly every two months Hydroxocobalamin is preferred over cyanocobalamin in the UK due to superior retention and fewer injections required
The capsule formulation provides an oral delivery route rather than reconstitution for injection
Paramount runs continuous HPLC on both raw materials and finished products
