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The proposed reason the combination is more than the sum of its parts is that amylin agonism appears to sensitize hypothalamic leptin signaling
Saito Y, Takahashi T, Obata Y, Nishida T, Ohkubo S, Nakagawa F, et al
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10.1016/s0092-8674(00)81732-8 Cell 43 CeniniG.LloretA.CascellaR
Morabito R, Remigante A, Di Pietro ML, Giannetto A, La Spada G, Marino A
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