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PMID: 18205187

It has been shown that both COVID-19 and PCC may be risk factors for long-term neurodegeneration, firstly due to chronic neuroinflammation of the neurovascular unit as we describe in Figure 2, but it may also be due to the fact that the SARS-CoV-2 nucleocapsid protein (N-protein) considerably speeds up the -synuclein aggregation process formation that leads to the formation of multiprotein complexes and eventually amyloid fibrils, which could increase the risk of triggering Parkinsons and Alzheimers disease [60]

The forkhead box O (FOXO) family of transcription factors is activated by JNK after ROS levels are increased and induces the expression of SODs and catalase 24

J Carcinogen 5:14 Demple B, Harrison L (1994) Repair of oxidative damage to DNA: enzymology and biology

Butterworth Heinemann, Oxford, UK, pp 227261 Lan T, Yang Z-L, Yang X, Liu Y-J, Wang X-R, Zeng Q-Y (2009) Extensive functional diversification of the Populus glutathione S-transferase supergene family

Although high doses of curcumin and turmeric extracts have not increased mortality in mice, adverse effects have been observed in other species (49)
