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Transcriptomic profiles in human pericytes isolated from the prefrontal cortex and the hippocampus show an upregulation of apoE4 both at the transcript and at the protein levels compared to apoE3 [67]

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In other words, EGCG was able to extend autophagy, thereby delaying apoptosis mediated cell death and eventually extending cell viability [164]

The above changes were alleviated after the administration of lower and higher-dose ALCAR