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Food and Drug Administration) Long-term data are limited
Indeed, diamide shortened the lifespan of animals fed DB (Supplementary Fig
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N, number of participants
Table S3), suggesting its protective role against oxidative damage
Excess ROS acts as a second messenger and regulates the function of important proteins, including Kelch-like ECH-associated protein 1 (Keap1), protein kinase C (PKC), and IB kinase by interacting with the cysteine residues (known as redox sensors) and causes their oxidation [10,25]
