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However, in line with our observation of elevated ser/gly synthesis in HIF2 KO NSCLC cells, HIF2 deficient renal cell carcinoma (RCC) cells showed upregulation of ser/gly synthesis pathway and presented enhanced sensitivity to the inhibition of this pathway using the phosphoglycerate dehydrogenase (PHGDH) inhibitor NCT-503 [57]
No conditional release exists in the workflow, so a partial pass puts the lot on hold pending resolution
Kraun D, Lopes LR, Cifuentes-Pagano E, Pagano PJ
Shi L, Fu W, Xu H, Li S, Yang X, Yang W, et al
doi: 10.1002/jsfa.3785
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