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In senescent endothelial cells induced by OGD, treatment with FOXO4-DRI led to a significant increase in the expression of BAX and cleaved caspase-3 (c-Caspase-3), while the expression of BCL2 notably decreased

All animals were sacrificed in the sixth post-operative week

Deep Dive: The Science of the "Innate Repair Receptor" We mentioned the IRR earlier, but it deserves a closer look because it is the cornerstone of why this protocol works

Note that the patients are not consulted they are just dictated to