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Inhibitors of NF-B block the TMAO-induced enhancement of leukocyte adhesion to the aortic endothelial layer [38]
For instance, AARS1-mediated lactylation of p53 at lysine 120 and lysine 139 promotes breast cancer by disrupting its phase separation, DNA binding, and activation of p21 and PUMA
In high concentrations taurine is present in the heart to help regulate the heartbeat
iScience 24(9):102944 2021 PMC8368994 Beltejar MG, Lau HT, Golkowski MG, Ong SE, Beavo JA
Identified Sir2 as the first sirtuin-family deacetylase in yeast
Oct 2021;86:7-18
