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The concern primarily stems from research indicating that excessive levels of L-carnitine might lead to increased production of trimethylamine-N-oxide (TMAO), a compound linked to cancer and heart disease

Second, animal studies indicate that acetyl-L-carnitine

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If G binds to the T 5 helix of the TIM barrel-like domain, the same orientation effects could occur, but there may also be a significant allosteric component to activation because this helix contacts two autoinhibitory elements, the XY linker and H 2 helix (Fig