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Excessive eating, lack of exercise, and obesity can lead to long-term imbalances in energy metabolism, which may result in increased reactive oxygen species production

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Metabolism-based targets exert a very low variability and are predictably essential for viral replication, resulting in a high resistance barrier and a predictable broad antiviral activity

Emerging Strategies and Future Directions 12.1

In the polyol pathway, glucose is converted to sorbitol by the enzyme aldose reductase (AR)a reaction that depends on the donation of an electron from the cofactor NADPH which then becomes NADP + (Figure 4)