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Significance was set at less than or equal to 0.05

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Despite this, there is disagreement among these studies, with mtDNA-HG disease associations being revised by new studies that utilize more advanced analysis methods and larger sample sizes [112,113,114]

ztrkler Y, Yildiz S, Gngr O, et al

It means the evidence lacks the independent replication that builds scientific confidence

Mitochondria cannot manufacture glutathione de novo , so glutathione is synthesized in the cytosol and a small fraction of the total cellular pool is then imported into the mitochondrial matrix by carrier-mediated transport (22