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This was also confirmed by Gross et al., who indicated that migraine can, in some part, be related to energy deficits in the brain and the experienced pain stems from brain hypometabolism and oxidative stress triggered by the factors commonly causing headache (e.g., fasting, physical exertion, excess sleep or sleep deprivation, intense aromas, or photosensitivity) due to their direct or indirect effect on energy metabolism and mitochondrial activity [22]

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Metabolic effects of a synthetic fragment of human growth hormone. Metabolism, 49(11), 14911496