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10.1021/acs.analchem.5b00786

The pyrazole group interacts with P33, while the side chains of residues M29 and L56 from the G-site interact with the acetamide group
Comparative Effectiveness of First-Line Medications for Primary Open-Angle Glaucoma: A Systematic Review and Network Meta-analysis

Available in a nasal spray bottle

Besides, it is possible to add mucoadhesive agents to the formulation, which can improve biodistribution by increasing the retention time in the brain and the brain/blood ratio [111]
