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If haptocorrin levels fall for some reason, the total B12 will decrease even though the functionally important B12 bound to transcobalamin II is normal

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[DOI] [PubMed] [Google Scholar] 34.Bose D., Su Y., Marcus A., Raulet D.H., Hammond M.C

Such heterogeneity can lead to a 35-fold variation in therapeutic efficacy of the same ferroptosis inducer across different patients, severely limiting clinical predictability

10.1016/j.intimp.2018.05.034