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Well, ideally you want the biotinylation of your protein to not interfere with its function

Comparison of nuclear 5 alpha-reductase activities in the stromal and epithelial fractions of human prostatic tissue

The Nobel Assembly said in a news release Monday that the three scientists made seminal discoveries that led to the identification of a novel virus. It said the trio had made a decisive contribution to the fight against blood-borne hepatitis, a major global health problem that causes cirrhosis and liver cancer in people around the world. Globally, an estimated 71 million people have chronic hepatitis C virus infection, according to the World Health Organization

So, when people talk about NAC, the conversation usually leads quickly to glutathione

showed that a specific mutation in p53 (3KR mutant that cannot be acetylated on certain lysine residues) causes cancer cells to lose the ability to induce cell cycle arrest or apoptosis