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Berberine protects secondary injury in mice with traumatic brain injury through anti-oxidative and anti-inflammatory modulation

A study in 2022 used this model to screen out a novel ALK5 inhibitor, TP-008, which reduced collagen deposition in mouse pulmonary fibrosis models by 70% (Luttens et al., 2025)

1 When toxic doses of acetaminophen are ingested, the metabolic pathways become saturated, resulting in high levels of NAPQI that deplete glutathione stores, eventually resulting in hepatic necrosis

10.1056/NEJMoa1811867 145 Nyang'waB

AC has shown potential in reducing blood pressure through several mechanisms

Biometals 17 , 6578 (2004)