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Alpha-1 antitrypsin (A1-PI) treatment slows emphysema progression independent of baseline FEV1

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This initial recognition not only triggers epithelial cell-autonomous responses (e.g., barrier reinforcement, secretion of proinflammatory cytokines) but also primes the subsequent recruitment and activation of innate immune cells

Nat Rev Cancer 5(9):726734 Kong L, Tanito M, Huang Z, Li F, Zhou X, Zaharia A et al (2007) Delay of photoreceptor degeneration in tubby mouse by sulforaphane

Theruvathu JA, Jaruga P, Nath RG, Dizdaroglu M, Brooks PJ

Immunization with P28GST (schistosome enzymatic protein) reduced colitis lesions and pro-inflammatory cytokine expression, associated with significant eosinophil infiltration in the colon