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The two compounds have complementary tissue repair mechanisms

The narrative format was selected to accommodate heterogeneous evidence spanning preclinical mechanisms, clinical trials, and translational barriers where systematic synthesis would be inappropriate

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On the other hand, chronic GC exposure is associated with adipose tissue expansion, suggesting an increase in total body lipogenesis and, despite a possible increase in lipolysis, a positive balance of lipid storage in adipose tissue

The study found that while low to moderate doses (2.5-250 g) provided some benefit, daily doses of around 500 g or more were required to restore healthy B12 levels