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Arginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its L-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability

The shrinking or wasting away of cells, organs, or tissues that may occur as part of a disease process, trauma, or aging

doi: 10.1016/j.jacc.2021.12.017 6

(3) Systemic metabolic dysregulation: Inhibition of MPC and ALT2 disrupts the coordination between hepatic gluconeogenesis, the TCA cycle, and inter-organ metabolic signaling (e.g., Cori cycle and Cahill cycle), ultimately compromising TCA cycle function [51]

Measurements were taken in a BioTek Synergy H1 microplate reader

supplementation on inflammatory and oxidative stress indicators: a systematic review and meta-analysis of controlled clinical trials