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doi: 10.1016/j.ijbiomac.2017.12.136 177 Valdez-MiramontesC

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CYP27A1 effectively catalyzes the first rate-limiting step in the alternative pathway, while 7-hydroxysteroid 7-hydroxylase (CYP7B1) participates in subsequent 7-hydroxylation, responsible for the majority of CDCA synthesis (Mihalik et al., 2002)