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Spragleys specializations and interests include non-surgical management of cranial cruciate ligament tears, Intervertebral Disk Disease(IVDD), and pain management in osteoarthritis

Yet, amidst the chatter, it's not uncommon to find a haze of confusion

Orthogonal validation of NMR fragment hit 27 Encouraged by the relatively high binding affinity of compound 27 compared to expectations for fragments, we synthesised a series of analogues to explore the effect of modifying both the sulfonic acid and the ethoxy substituents on binding affinity (Table 1)

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The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton
