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Lee SMC, Feiveson AH, Stein S, Stenger MB, Platts SH

The more consequential development for DCT neurology market growth is the FDA and EMA's increasing receptivity to digital outcome assessments (DOAs) as primary endpoints in pivotal rare disease submissions a position reflected in growing scientific advice correspondence and in the number of Phase III neurology programs formally designating DOA instruments as primary or key secondary endpoints

10.1089/ars.2006.8.1865

Tumor-intrinsic pathways include enhanced DNA repair, apoptosis evasion, metabolic reprogramming, and transcriptional or epigenetic plasticity, while tumor microenvironmental influences such as hypoxia, immune suppression, and stromal remodeling further sustain resistant phenotypes

Deuterium-Isotope Effects in the Autoxidation of Aralkyl Hydrocarbons
Although arginine is necessary for growth but not body maintenance, research has indicated that arginine is crucial to the wound-healing process, particularly in those with poor circulation
