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As the ANKIB1-RBR was not required for TLR3-SC recruitment, we next examined the role of ANKIB1s ubiquitin-interacting motif (UIM), a domain type previously reported to mediate polyubiquitin-chain binding (Extended Data Fig

M1 macrophages, induced by Toll-like receptor ligands (e.g., LPS) or Th1 cytokines such as TNF-, IFN-, and colony-stimulating factor 2 (CSF2), are characterized by surface expression of TLR2, TLR4, CD80, and CD86 (84)

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5a) did not reliably quantify any GSS-CAM-TPP

The phospholipids composed of PUFAs (PUFA-PLs) undergo peroxidation in the cell membrane, producing lipid hydroperoxides that react with iron, leading to ferroptosis [40]