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The word "hypodermic" comes from the Greek hypo (under) and derma (skin)

All authors reviewed and approved the final version of the manuscript

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Tumour necrosis factor-alpha (TNF-) suppresses insulin signalling [33], interleukin-6 (IL-6) directly induces inflammation or enhances the release of hepatic C-reactive protein [34], while interleukin-8 (IL-8) activates neutrophil granulocytes

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