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Both AKR1B1 and AKR1B10 possess a negatively charged acidic hydroxyl group (Tyr48) in the catalytic site that may be important in structure-based drug design [43]

D.et al (2005)

This study showed that perindopril preserved the goblet cells in the villi/crypts and reduced the histological abnormalities, indicating that the intestinal injury had been attenuated
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doi: 10.1007/s00203-021-02377-5 [DOI] [PubMed] [Google Scholar] 138.Hiradeve SM, Rangari VD

Pharmacologic and genetic suppression of GPX4 induces ferroptosis, DNA damage, and decreased cell viability in vitro via a novel mechanism of mTOR signaling pathway inhibition