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Beyond drug delivery considerations ( 6, 10 ), this pathologic feature is associated with low microvascular density ( 6, 11 ), tissue hypoxia, and steep nutrient gradients ( 12, 13 )

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[DOI] [PubMed] [Google Scholar] 303.Thrainsdottir, S

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To address this issue, a hydrogel-based bioadhesive dry powder has been developed for pulmonary inhalation, with particles smaller than 5 m in diameter, allowing for deeper lung deposition 30,31

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For first time IV users wanting to limit necessary respiratory eliminations, however larger sinus and lung evacuations may occur

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