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1 Treatment based on a fixed-dose combination tablet (FDC) is preferred 2 for both primary and secondary prevention 3 under the B101 drug programme or the rescue access to drug technology (RDTL) procedure Table VIII New Lp(a)-lowering medicines under clinical development Management of elevated Lp(a) concentrations Currently, there are no approved medicines targeting the lowering of Lp(a) concentrations, and therefore, with elevated Lp(a) values, the recommended management is aimed at lowering overall risk through lifestyle changes, and intensive treatment or optimisation of treatment of other risk factors that can be effectively treated according to current recommendations (Figure 3 and Table V) [88, 100])

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