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3D imaging of tissue cleared iWAT an adipose-specific inducible PRDM16 knockout showed silencing of PRDM16 during post-natal days 628 caused a reduction in early post-natal beige adipocytes and sympathetic neurite density (Chi et al., 2021)

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This potential is posited to be mediated via the MC4 receptors, which might even promote neurite outgrowth and possibly support the intrinsic capacity of neuronal tissue to recover after injury