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Secondly, IC-PAD experiments confirmed the selective acrolein scavenging of GSH and of NAC (Fig

Neuron (2013) 78(1):13851

These results suggest that low glutamine in the tumour microenvironment, similar to hypoxia, may drive cancer progression and augment resistance to treatment via epigenetic regulation

Among the antioxidants shown to be protective in animal models of influenza are the xanthine oxidase inhibitor allopurinol, 54 quercetin, 58 superoxide dismutase, 59 thioredoxin, 60 NAC (alone 61 or with ribavirin 62 or oseltamavir 63 ), and GSH itself

287,344 Collectively, these interactions illustrate that the transcriptional and epigenetic regulators of autophagy operate through interdependent mechanisms

For example, loss of Purkinje cells leads to anterograde trans-synaptic degeneration of cerebellar nuclei and retrograde trans-synaptic degeneration of cerebellar granule cells