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An obvious explanation for these observations is that EST expression is high in male WAT (320) to protect from excessive estrogen actions

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Besides, TMAO promotes platelet hyperreactivity and thrombosis by increasing intracellular Ca 2+ release [359]

In summary, the involvement of GSH in the carcinogenesis and in the drug resistance of tumor cell is clear, but further studies, aimed at understanding the GSH-driven molecular pathways, might be crucial to design new therapeutic strategies to fight cancer progression and overcome chemoresistance

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Figure 6 illustrates how systems-based theories can bridge Eastern and Western models, as well as connecting ancient and modern ideas