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Tolosa, E., Wenning, G

A comprehensive review on NIH/PMC documents that GHK-Cu cream applied twice daily for 12 weeks strongly stimulated dermal keratinocyte proliferation, increased skin thickness, improved skin hydration, increased collagen I production and improved skin elasticity in clinical study participants

Note on solvent selection: Bacteriostatic water is strongly preferred over plain sterile water for research vials that will be accessed multiple times

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Therefore it should never be used as a plain IV fluid only used to reconstitute or dilute medications, which typically make the final mixture isotonic