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Mounjaro is a dual agonist: it works on two hormone receptors (GLP-1 and GIP)

The main enzyme involved, dipeptidyl peptidase-4 (DPP-4) also known as CD26, cleaves off the two N-terminal residues resulting in GLP-1 (9-36 amide) which is inactive or acts as an inhibitor at the GLP-1 receptor (23)

Participants were randomly assigned to receive a once-weekly injection of 2.4 milligrams (mg) of Wegovy or placebo, alongside lifestyle counseling, over a 72-week period (nearly a year and a half)

No statistically significant differences were observed between GLP-1 RA and DPP-4i users for atopic dermatitis, vitiligo, dermatomyositis, alopecia areata, lichen planus, cutaneous lupus erythematosus, hidradenitis suppurativa, systemic sclerosis, pyoderma gangrenosum, or morphea

and Pesta, D

How to tell if shedding is from rapid weight loss or genetics