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Interestingly, chronic chemo-genetic stimulation of POA LepR-expressing neurons decreases both food intake and energy expenditure, and results in body weight loss, indicating that the reduced food intake surpasses the decreased energy expenditure [28]

This is a large development in the world of GLP-1 RA litigation

Rosenstock J, Balas B, Charbonnel B, et al

[DOI] [PubMed] [Google Scholar] 31.Wjcik P, Ggotek A, arkovi N, Skrzydlewska E

Alternatively, can we identify the cardioprotective mechanisms of GLP-1 action and extend the therapeutic possibilities of GLP-1 therapy to nondiabetic subjects at high risk for cardiovascular disease

Day JW, Ottaway N, Patterson JT et al (2009) A new glucagon and GLP-1 co-agonist eliminates obesity in rodents