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In this issue of the JCI , Farokhnia and colleagues used a reverse translational approach to examine the effects of enhancing GLP-1R activity either through synthetic agonists or inhibition of its degrading enzyme, dipeptidyl peptidase-4 (DPP-4) on alcohol consumption in both humans and preclinical models (Figure 1) (4)

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Hybrids 5 and 9 showed efficacy but no improvement, indicated by a similar blood glucose curve to peptide 1 (Fig

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This magnitude of A1C improvement typically requires multiple diabetes medications when achieved through conventional treatment approaches

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