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That covers: Fasting glucose (basal insulin) Post-meal glucose (GLP-1) Weight loss (GLP-1) Cardiovascular protection (GLP-1) The COMBINE Phase 3a trials have already shown superior HbA1c reduction with a lower insulin dose and non-inferior control vs

The US Food and Drug Administration approveddrugmaker Novo Nordisks application to add cardiovascular benefits to the medicines label, making it the first weight-loss drug to also be cleared to reduce the risk of heart attack, stroke or heart-related death in people at higher risk of these conditions.

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The glucose-lowering and weight-reducing drug class appears to benefit the heart and kidneys in people with lupus and lupus nephritis, independently of glucose-lowering and weight loss.