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Generally speaking, when you gain weight, it means youre eating more calories than your body is burning

Kivipelto, A

[37] observed that after internalization, GLP-1R/ligand complex could be co-localized with adenylate cyclase in the endosome

This could help distinguish whether the observed increases in gestational weight gain, GDM, and hypertensive disorders reflect a rebound effect after discontinuation versus the underlying metabolic risk profile of the treated population

CrossRef Pediatric non-alcoholic fatty liver disease: New insights and future directions Pierluigi Marzuillo World Journal of Hepatology.2014

These areas are accessible to circulating peripheral GLP-1 and thus may permit direct effects of this peptide in the central nervous system (CNS)